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Alzheimer’s Disease (AD) is an incapacitating neurodegenerative condition without any known cure. The increasing occurrence of this disease presents a considerable challenge. Researchers are investigating better treatment strategies by studying both organic and synthetic alternatives. 

There have been numerous clinical trials that demonstrate the promising potential of serotonergic psychedelics such as LSD, DMT, and psilocybin in the treatment of Alzheimer’s disease. For more fascinating information, you are encouraged to explore online resources or consider “purchasing psychedelics online in Canada.”

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The Contribution of Psychedelics to Alzheimer’s Treatment

Traditional psychedelics demonstrate potential in the treatment of early-stage Alzheimer’s Disease (AD) or mild cognitive impairment (MCI) by stimulating the development of brain cells.

Psychedelics could stimulate neural plasticity for learning and memory by targeting specific brain receptors. This might potentially slow or even reverse the neurodegenerative effects of AD. In addition, psychedelics could potentially ease depression and anxiety, often seen in AD patients, by creating positive psychological impacts.

There are still unresolved questions about how psychedelic treatments function. Some suggest that profound effects experienced from high-dose psychedelics, such as mystical sensations or a feeling of self-dissolution, are vital for reaping psychological benefits. Others believe that the critical factor is the biological alterations induced by these substances. Both viewpoints may have merit.

Traditional psychedelics appear to aid the brain in adjusting and reducing inflammation, even at lower doses. Hence, low-dose treatments could be beneficial for conditions like brain degeneration or migraines without significant mind-altering effects. However, for depression, anxiety, or addiction, the mind-altering effects seem essential, leading to introspection and behavioural changes. Therefore, both low and high doses deserve investigation for personalized therapy.

The Impact of Serotonergic Psychedelics

Serotonergic psychedelics, such as LSD (lysergic acid diethylamide), DMT (dimethyltryptamine), and psilocybin (found in magic mushrooms), are gaining

The potential therapeutic effects of psychedelics on a range of mental health disorders have sparked growing interest.

Experts believe that serotonin receptors, celebrated for their cognitive enhancement and neuroplasticity modulation abilities, could be a promising focus for Alzheimer’s Disease (AD) research.

Psychedelics mainly exert their pharmacological effects by modifying the brain’s serotonin system, leading to alterations in perception, mood, and consciousness. Several studies corroborate this theory, as outlined below:

  • Specifically, the 5-HT2A subtype of serotonin receptors can affect neuroplasticity-enhancing neurotrophins gene expression in the brain regions impacted by AD.
  • These receptors govern cortical signalling, critical for cognition, memory, and synaptic plasticity.
  • Despite a unique distribution within neurons, serotonin receptors play integral roles in neural development, regeneration, and plasticity.

Significant Research Findings

  • Serotonergic psychedelics show potential in alleviating AD pathology by promoting neuroplasticity.
  • Classic psychedelics can influence neurotransmission, stimulate synaptic remodelling, and enhance factors that promote neuronal survival.
  • Specific psychedelics like muscimol and Sig-1R agonists might lessen the neurotoxicity associated with AD progression.
  • Classic psychedelics activate pathways in brain regions impacted by AD, indicating potential to slow or even reverse brain degeneration.
  • Psilocybin mushrooms initiate neural plasticity, stimulate neurogenesis and effect long-lasting changes in brain circuits.
  • Psychedelics can enhance brain connectivity by targeting receptor genes and triggering alterations in neurons and networks.

Clinical studies demonstrate that both classic and non-classic psychedelics from magic mushrooms can influence several biological processes in the brain. This includes rapid changes in gene expression and significant modifications in brain structure and function.

These psychedelics interact with receptors like serotonin, sigma, NMDA, and GABA, leading to enhanced synaptic plasticity and brain rejuvenation. As a result, psychedelics may have favorable impacts on behaviour, memory, and cognition, presenting them as potential therapeutic options for AD and similar disorders.

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  1. LSD

LSD, a man-made drug, is derived from a fungus called ergot that grows on rye grains. This potent psychoactive substance can dramatically modify perceptions, emotions, and thoughts, even in small quantities.

Excessive intake of LSD can induce powerful hallucinations that distort your sense of time and space. Be careful, as substances marketed as LSD might in reality be other drugs such as NBOMe or members of the 2C drug family.

ProductKittease – Ketamine Microdose Troche (30x50mg)Zenly – LSD Gel Tabs – 600ug (100ug Per Tab)Zenly – LSD Gummies – Sour Zen Berry – 200ug (100ug Per Gummy)
Intended UseStress, depression, pain control, PTSD, OCD, workplace stress, performance anxiety, sleep disorders, and addiction.Extraordinary experiencesExtraordinary experiences
Dosage50mg per troche / 30 per package – 1.5 grams of ketamine per package600ug total/6 Tabs (100ug/Tab)200ug total/2 Gummies (100ug/Gummy)
Usage GuidelinesConsume one full trocheIngest one full tab to feel the full effect. Wait a minimum of 2 hours before taking another.Consume one full gummy to experience the entire effect. Wait at least 2 hours before consuming another.
BenefitsQuick action with reduced risk, enhanced receptivity, ideal for introspection and cognitive improvement.Accurately dosed for the perfect trip, lab-confirmedAccurately dosed for the perfect trip, lab-confirmed
  1. Magic Mushrooms

Over 180 species of mushrooms are identified as containing psilocybin and psilocin, compounds celebrated for their therapeutic qualities and positive effects. on mental health. 

The effects can vary based on the species of the mushroom, the batch in which it was cultivated, the amount consumed, and the individual’s tolerance level. While some people prefer microdosing for its subtle effects, others may consume larger doses for a more intense experience. The quality of the mushrooms can also differ based on the cultivation methods used.

Blue Meanies, scientifically referred to as Panaeolus cyanescens, are small dried fungi that flourish in warm tropical climates, often found on cow and water buffalo dung. As they grow, they develop blue spots on their surface, giving them their distinct name.

  • These fungi are rich in psilocybin and psilocin, which are highly concentrated. 
  • They have been traditionally used for recreational purposes, especially among the Balinese people, who consume them during celebrations and for artistic inspiration.
  • They are popular among tourists and travelers in Bali and similar places due to their hallucinogenic properties. Their effects may include feelings of euphoria, hallucinations, joy, and intense laughter.
  1. DMT

DMT, a potent hallucinogenic compound, is found in certain plants like Psychotria viridis and Chacruna. Often dubbed the “spirit molecule,” these controlled substances can provide intense psychedelic experiences. They offer a short yet highly immersive journey characterized by vivid visual and auditory hallucinations. 

ProductDream Machine – Vape Cartridge – DMT 1mlIntegral Alchemist – ACACIA Changa Pre-RollIntegral Alchemist – Mimosa- 1ml DMT Vape Cart
DescriptionExplore hyperdimensional realms with DMT.Encounter effects akin to ayahuasca, with a blend of herbs and DMT.Embark on a journey of mystical visions and profound spiritual insights with DMT.
DMT Content1gApproximately 90mg1ml
InstructionsPreheat the cartridge and inhale Consume the pre-roll at a pace that suits you.Inhale the vapor to experience immediate effects.
EffectsIntense hallucinations, altered state of consciousness.A visual, psychedelic trip of extended duration.Experiences of spiritual enlightenment, euphoria, and significant changes in perspective.
DurationVaries by individualLasts up to 1 hourEndures for up to 30 minutes

The Long-Term Effects of Psychedelic Use

Current research aims to comprehend the long-term implications of consuming psychoactive substances. As our understanding in this field continues to expand, the term “long-term effects” is used to describe any lasting changes in cognitive function, emotions, or memory following extensive psychedelic use.

The study of long-term consequences of using psychedelics is complex. While some studies suggest potential benefits for mental health, others point towards potential risks, such as an increased likelihood of psychosis.

Despite these complexities, scientists are persistently working towards understanding the effects of long-term psychedelic use on mental health. They conduct thorough research and monitor subjects over lengthy periods to collect more accurate data.

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Research suggests a substantial shift in Alzheimer’s disease treatment, indicating that psychedelics could dramatically change how we approach brain disorders. Experts believe that the therapeutic application of these substances could completely alter Alzheimer’s treatment, offering a new ray of hope for numerous patients and their families.

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Frequently Asked Questions

How do psychedelics differ from other substances typically used in Alzheimer’s treatments?

Psychedelics distinguish themselves from traditional Alzheimer’s medications by their therapeutic approach and effects. By targeting the brain’s serotonin system, they stimulate new neural connections, leading to profound psychological experiences that foster emotional health.

Unlike conventional drugs that primarily manage symptoms, psychedelics are being assessed by Health Canada for their lasting benefits and holistic treatment approach, which includes therapy.

Research into the use

The potential of psilocybin to treat disorders like obsessive-compulsive disorder and its safety record in terms of not causing multi-system organ failure differentiates it from typical controlled substances.

Is psychedelic-assisted therapy a viable treatment for Alzheimer’s patients facing end-of-life stress?

Psychedelic-assisted therapy could offer benefits to Alzheimer’s patients who are critically ill and struggling with the imminent reality of their mortality.

  • Offers emotional respite. This therapy is known to mitigate feelings of anxiety and depression in some individuals, especially those who are acutely ill. This could be beneficial to Alzheimer’s patients as well.
  • Generally safe when supervised. When provided in a controlled setting under the supervision of a trained therapist, the use of psychedelics is typically harmless and well received by most individuals.
  • Potentially improves quality of life. An emotional boost can make a substantial difference to an Alzheimer’s patient, even if there’s no change in memory issues.
  • Further research is required. Though promising, additional investigations are needed to validate the safety and effectiveness of this therapy for Alzheimer’s patients, especially those in the late stages of their lives.

What is the timeline of a psychedelic therapy session for Alzheimer’s patients?

  1. Preparation Stage. This stage involves one or two sessions, each spanning between 1 to 2 hours. These sessions aim to prepare the patient for the ensuing experience, establish expectations, and build trust with the therapist.
  2. Main Psychedelic Session. This crucial session, during which the patient consumes the psychedelic substance, typically extends between 4 to 6 hours. The patient spends this time in a controlled setting, often lying down with eye coverings and listening to music, under the therapists’ vigilant supervision.
  3. Integration Stage. After the session, follow-up meetings are arranged to help the patient interpret and incorporate their experience. These meetings usually last 1 to 2 hours each, with the total number of sessions varying.

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